The 2021–22 San Antonio Spurs season was the 55th season of the franchise, its 46th in the National Basketball Association (NBA), and its 49th in the San Antonio area.
For the first time since 2010–11, long-time point guard Patty Mills was not on the roster, as he signed with the Brooklyn Nets on August 10, 2021.
Mills' departure made sixth-year point guard Dejounte Murray the new longest tenured player on the roster.
On April 5, 2022, the Spurs became the 20th and final team to clinch a postseason position, clinching a spot in the elimination round in the play-in tournament for the second consecutive year, qualifying for the second consecutive year in the first stage as the No.
However, they lost to the New Orleans Pelicans in the Play-In tournament, eliminating the Spurs from playoff contention for the third consecutive season.