[1] A difference from recent seasons was that five clubs were given a bye to the last 16 instead of four, due to increased representation in European competition.

[1] The domestic broadcasting rights for the competition are held exclusively by Premier Sports, who became the tournament's title sponsor in April 2021.

[3] They were eliminated in the semi-finals by eventual winners Celtic, who won their 20th title after beating Hibernian 2–1 in the final.

Due to a fifth Scottish team participating in European competition and receiving a bye to the second round, an extra spot was available in the group stage.

The draw for the group stage took place on 28 May 2021 and was broadcast live on FreeSports & the SPFL YouTube channel.

The draw for the semi-finals took place on 23 September 2021 live on Premier Sports following the Celtic v Raith Rovers match.