The season was played with 10 teams;[1] original participants Forfar Farmington resigned suddenly in August 2021[2] and Partick Thistle were elevated to SWPL 1 to maintain an even number of teams (leaving SWPL 2 one short).
[5] Glasgow City were the defending champions of 14 consecutive seasons.
In February 2022, Glasgow City lost 3–1 away to Rangers in a pivotal fixture;[6] a 0–0 draw in the reverse fixture on 8 May gave Rangers the SWPL 1 championship, their first Scottish women's title.
[7] The Gers finished seven points ahead of Glasgow City and only dropped four points, via two draws against the deposed champions, defeating all other opponents three times for an unbeaten season.
[9] The league's first promotion/relegation play-off had been planned[10] until the expansion was confirmed in April 2022[9] following the SWPL clubs' majority vote to leave SWF for the SPFL in February.