The season covered the period from 1 July 2021 to 30 June 2022.

The Iron announced they would have friendlies against Barton Town,[3] Farsley Celtic,[4] Burton Albion,[5] Hull City,[6] Lincoln City[7] and AFC Wimbledon[8] as part of the club's pre-season preparations.

Source: [citation needed] Scunthorpe's league fixtures were revealed on 24 June 2021.

[11] Scunthorpe were drawn at home to Doncaster Rovers in the first round.

[13][14] Iron were drawn into Northern Group E alongside Doncaster Rovers, Manchester City U21s and Rotherham United.