The 2021–22 Segona Divisió, also known as Lliga UNIDA,[1] was the 23rd season of second-tier football in Andorra.
Ordino won the league the previous season, and were promoted to the Primera Divisió.
UE Extremenya returned to the league after not participating the previous season.
Jenlai withdrew from the league and all of their results were void.
The seventh-placed team, third-placed in the relegation round, from the Primera Divisió and the runners-up from the Segona Divisió played a play-off over two legs for a place in the 2022–23 Primera Divisió.