The 2021–22 Segunda División RFEF season was the first for the Segunda División RFEF, the new fourth highest level in the Spanish football league system.
[1] Ninety teams will participate, divided into five groups of eighteen clubs each based on geographical proximity.
In each group, the champions automatically promoted to Primera División RFEF, and the second to fifth placers will play promotion play-offs.
[2] The last five teams in each group will be relegated to the Tercera División RFEF; in addition, the four worst teams classified 13th in their group will play play-offs to define the last two relegation places.
The following clubs have qualified for the 2022–23 Copa del Rey by virtue of their league finish after reserve teams were excluded: