The 2021–22 Serbian First League is the 17th season of the Serbian First League since its establishment.
The league consist of 16 teams: eight teams from the 2020–21 Serbian First League, six teams relegated from 2020–21 Serbian SuperLiga and two new teams promoted from Serbian League.
The top eight teams advanced from the regular season.
The bottom eight teams from the regular season play in the relegation round.
[2] 4 Player scored four goals