On 22 May 2022, following victory in their final match against Sassuolo, Milan were crowned champions for the first time since the 2010–11 season, earning a nineteenth overall title.
[3] Twenty teams competed in the league—the top seventeen teams from the previous season and three teams promoted from the Serie B. Crotone, Benevento (both relegated after only one year in the top flight) and Parma (relegated after three years in the top flight) were relegated to the 2021–22 Serie B.
On 4 May 2021, Empoli secured promotion to Serie A after a two-year absence.
[4] Six days later, Salernitana officially confirmed a return to the top flight after 22 years of absence.
1 Vlahović played for Fiorentina until matchday 23 and scored 17 goals.