In addition to the domestic league, Sevilla also participated in this season's editions of the Copa del Rey, the UEFA Champions League and the UEFA Europa League.

Win Draw Loss Fixtures Source: Soccerway Source: La Liga The league fixtures were announced on 30 June 2021.

[25][26] The draw for the group stage was held on 26 August 2021.

The knockout round play-offs draw was held on 13 December 2021.

Last updated: 27 February 2022Source: ESPNFC.comOrdered by , and = Number of bookings; = Number of sending offs after a second yellow card; = Number of sending offs by a direct red card.