[1] On 9 July, the club were hit with a suspended 6 point penalty, which will take effect if they fail to pay their players wages on time before June 30 2022.

[3] On 14 July, the club introduced their new first team scholars for the 2021–22; Pierce Charles, Jack Hall, Kamil Maciag, Tafadzwa Tapudzai, Cian Flannery, Bailey Cadamarteri, Josh Chapman, Danai Rhule, Rio Shipston, Mackenzie Maltby, Sean Fusire, Joey Phuthi and Jake Bradford.

[4] On 20 July, manager Darren Moore confirmed that first-team coach Paul Williams had left the club for personal reasons.

[9] On 13 August, Guiseley announced a loan move for goalkeeper Luke Jackson, but the deal would be cancelled the same day due to the keeper picking up an injury.

[10] On 27 August, the game against Sunderland was postponed due to the Black Cats having hit the criteria for players on international duty.

[26] On 2 July 2021, the remainder of their pre-season was announced, with games against, Chester, Alfreton Town, Barnsley, West Bromwich Albion, Wrexham and Port Vale all confirmed.

[27] On 16 July, they announced two more friendlies for a Sheffield Wednesday XI side against, Ossett United and Stocksbridge Park Steels.

[31] Sheffield Wednesday finished 4th in the regular 2021–22 EFL League One season, so were drawn against 5th placed Sunderland in the Play-off Semi Final.