Slovan Bratislava were the defending champions, defeating Žilina in the 2021 final.
Slovan Bratislava managed to advance to the final again, but were defeated by their rivals Spartak Trnava.
Spartak Trnava earned automatic qualification for the UEFA Europa Conference League second qualifying round.
The Slovak Cup is played as a knockout tournament.
All matches that end up as a draw after 90 minutes are decided by penalty shoot-outs.