A total of fourteen teams contested this season's league, which began on 10 September 2021 and concluded on 27 May 2022.
[1] Celje won their twenty-fifth title.
[2] Krka and Izola were relegated in the previous season.
Šmartno and SVIŠ were promoted from the second division.
The following 14 clubs competed in the Slovenian First League during the 2021–22 season: