The tournament began on 15 September 2021 and ended on 11 May 2022 with the final.
[1] Due to the COVID-19 pandemic in Slovenia, the Intercommunal Regional Cup competitions were not held in the 2020–21 season; as a result, only all ten teams of the 2020–21 Slovenian PrvaLiga and the best two teams of the 2020–21 Slovenian Second League entered the competition.
[2] Olimpija Ljubljana were the defending champions after winning the previous season's final.
[3] Koper won their fourth title after beating Bravo 3–1 in the final.
[4] As winners, they earned a place in the second qualifying round of the 2022–23 UEFA Europa Conference League.