The 2021–22 South Carolina Gamecocks men's basketball team represented the University of South Carolina during the 2021–22 NCAA Division I men's basketball season.

The team was led by 10th-year head coach Frank Martin, and played their home games at Colonial Life Arena in Columbia, South Carolina as a member of the Southeastern Conference.

7 seed in the SEC tournament, they lost to Mississippi State in the second round.

On March 14, 2022, the school fired head coach Frank Martin.

11 seed in the SEC tournament they lost in the first round to Ole Miss.