The 2021–22 South Dakota Coyotes women's basketball team represented the University of South Dakota in the 2021–22 NCAA Division I women's basketball season.

The Coyotes were led by sixth-year head coach Dawn Plitzuweit and competed in the Summit League.

They played home games in Sanford Coyote Sports Center in Vermillion, South Dakota.

Surprising Ole Miss, the Coyotes upset 2nd seeded Baylor to advance to the Sweet Sixteen for the school's first time.

Shortly after the season, she left for the head coaching vacancy at West Virginia.