The 2021–22 South Dakota State Jackrabbits men's basketball team represented South Dakota State University in the 2021–22 NCAA Division I men's basketball season.

The Jackrabbits, led by third-year head coach Eric Henderson, played their home games at Frost Arena in Brookings, South Dakota, as members of the Summit League.

13 seed in the Midwest Region, where they lost in the first round to Providence.

This was the first season in program history that the Jackrabbits eclipsed 30 wins in a single campaign.

They defeated Omaha in the quarterfinals of the Summit League tournament,[1] before being upset by the No.