The 2021–22 South Florida Bulls men's basketball team represented the University of South Florida during the 2021–22 NCAA Division I men's basketball season.

The season marked the 50th basketball season for USF, the ninth as a member of the American Athletic Conference, and the fifth season under head coach Brian Gregory.

The Bulls played their home games at Yuengling Center on the university's Tampa, Florida campus.

In a season limited due to the ongoing COVID-19 pandemic, the Bulls finished the 2020–21 season 9–13, 4–10 in AAC play to finish in a tie for eighth place.

They defeated Temple in the first round of the AAC tournament before losing to Wichita State in the quarterfinals.