[56] On 9 January 2022, the Saints were drawn at home to Coventry City in the fourth round.

[57] On 6 February 2022, the Saints were drawn at home to West Ham United in the fifth round.

[58] On 3 March 2022, the Saints were drawn at home to Manchester City in the quarter-finals.

[60][61] On 25 August, the draw for the third round was completed, with the Saints drawn away to Sheffield United.

[62][63] On 22 September, the draw for the fourth round was completed, with the Saints drawn away to Chelsea.