The season saw a change in manager and first team coaches following the sacking of Phil Brown.
Kevin Maher was recruited as first team coach, as well as multiple notable backroom-staff appointments, including former player, Stan Collymore as Senior Football Strategist and John Still as Head of Football.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.
Source: TheFishy The 2021–22 National League fixtures were announced on 7 July 2021.
[51] Southend entered the FA Cup at the fourth qualifying round.