The league constitution for this season was based on allocations for Steps 5 and 6 that were announced by The Football Association on 18 May 2021, and were subject to appeal.
Cockfosters, initially allocated to this division from the Essex Senior League, successfully appealed and the transfer was rescinded.
The 10 runners-up with the most points per game (PPG) at Step 5 were automatically promoted after the 2021–22 season.
The remaining six played one-off inter-step play-off matches with the six third-from-bottom clubs with the fewest PPG from the eight divisions at Step 4.
The 12 best second-from-bottom clubs on a PPG basis out of 16 that were at Step 5 were reprieved from relegation.