On 5 July 2021, Thiago Motta was appointed head coach, replacing Vincenzo Italiano who had left for Fiorentina.

[1][2][3] On 16 July, Spezia were banned from four transfer windows, starting in January 2022, after breaching FIFA rules on signing minors.

[5] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Fixtures Spezia announced a squad of 24 players to take part in pre-season training, beginning on 12 July 2021.