The Bonnies, led by 15th-year head coach Mark Schmidt, played their home games at the Reilly Center in Olean, New York as members of the Atlantic 10 Conference (A-10).

[1] They received an at-large bid to the National Invitation Tournament where they defeated Colorado,[2] Oklahoma[3] and Virginia[4] to advance to the semifinals.

[6] In a season limited due to the ongoing COVID-19 pandemic, the Bonnies finished 2020–21 at 16–5, 11–4 in A-10 play, to win the regular-season A-10 championship.

[7] They defeated Duquesne,[8] Saint Louis[9] and VCU to win the A-10 tournament.

[13] On August 6, the school announced it had hired former UMass player and Texas–Rio Grand Valley assistant Chris Lowe to replace Woodall.