[2] On April 16, 2022, the Blues clinched a playoff spot after a 6–5 overtime win against the Minnesota Wild.
[3] The Blues set a franchise record with a 16-game point scoring streak from April 1–24.
†Denotes player spent time with another team before joining the Blues.
Below are the St. Louis Blues' selections at the 2021 NHL Entry Draft, which were held on July 23 to 24, 2021.
It was held virtually via Video conference call from the NHL Network studio in Secaucus, New Jersey.