Under the continued management of Callum Davidson, St Johnstone were confident of building upon the previous season's success but the departures of some key players left the team in transition and results through the autumn of 2021 were poor.

Avoiding relegation became the priority and Saints were ultimately successful in that, although they finished eleventh (out of twelve) and had to overcome the challenge of Inverness Caledonian Thistle in the two-leg Premiership playoff.

Still managed by Callum Davidson, St Johnstone hoped to build upon their double success in the 2020–21 domestic cup competitions.

[2] By finishing eleventh, St Johnstone had to take part in the Premiership playoff where they met Inverness CT over two legs (home and away).

[3] In the home leg at McDiarmid Park three days later, Saints were clear winners by 4–0, the team's biggest victory of the whole season.

[5] Saints entered the Scottish Cup in the fourth round with an away tie at League Two club Kelty Hearts, who had been newly promoted to the SPFL that season.

[8] The defeat meant Saints could enter the inaugural UEFA Europa Conference League which they joined in the playoff round with a tie against Austria's Linzer ASK (aka LASK).