The winners of the competition will secure a spot in the second qualifying round of the 2022–23 UEFA Europa Conference League, unless they had already qualified for European competition in the 2021–22 season, in which case the qualification spot will go to fourth-placed team of the 2021 Allsvenskan.
A total of 96 clubs will enter the competition, 64 teams from district sites and 32 from the Allsvenskan and the Superettan.
64 clubs from the third tier or lower of the Swedish league system competed in this round.
The 16 highest ranked winners from the previous rounds were seeded to the top two positions in each group and the 16 remaining winners went unseeded in the draw.
The ranking of the 16 seeded teams was decided by league position in the 2021 season.