The number of U-21 teams permitted in this division was limited to four (this rule would be would be removed for the following season).
The table was then divided into three groups the teams taking points and goal difference with them.
The top six teams played a single round robin, against the other five, for the promotion slot.
The seven highest ranked (eligible) teams qualify directly to the first round of the 2022–23 Swiss Cup.
Therefore, the 2021–22 season saw three new clubs join the division, Chiasso, after suffering relegation from the 2020–21 Swiss Challenge League, and Young Boys U-21 and Biel-Bienne, who had both been promoted from the 1.