The 2021–22 Sydney Sixers Women's season was the seventh in the team's history.

Coached by Ben Sawyer and captained by Ellyse Perry, the Sixers were not scheduled to play any WBBL|07 games in their home state of New South Wales due to ongoing border restrictions related to the COVID-19 pandemic.

[1] They finished the regular season on the bottom of the ladder, and recorded more losses than wins, for the first time in the league's initial seven editions.

The Sixers also ended the tournament with six consecutive losses, mirroring their equal-longest losing streak which occurred at the beginning of WBBL|01.

[3] Personnel changes made ahead of the season included: Squad details during the season included: The table below lists the Sixers players and their key stats (including runs scored, batting strike rate, wickets taken, economy rate, catches and stumpings) for the season.