The 2021–22 Sydney Thunder Women's season was the seventh in the team's history.

Coached by Trevor Griffin, the Thunder entered WBBL|07 as the defending champions but ended the regular season in seventh place on the ladder, recording their worst finishing position across the league's first seven editions.

Due to ongoing border restrictions related to the COVID-19 pandemic, they were not scheduled to play any games in their home state of New South Wales for the season.

[1] After captain Rachael Haynes announced she would be unlikely to participate in the season due to family reasons, Hannah Darlington was appointed to stand in as Haynes' replacement.

[3] Personnel changes made ahead of the season included: Changes made during the season included: The table below lists the Thunder players and their key stats (including runs scored, batting strike rate, wickets taken, economy rate, catches and stumpings) for the season.