The 2021–22 Syracuse Orange men's basketball team represented Syracuse University during the 2021–22 NCAA Division I men's basketball season.

The Orange were led by 46th-year head coach Jim Boeheim and played their home games at the Carrier Dome in Syracuse, New York as ninth-year members of the Atlantic Coast Conference.

In the ACC tournament, they defeated NC State in the Second Round before losing to Virginia in the Quarterfinals.

They received an at-large bid to the NCAA tournament as an eleven seed in the Midwest Region.

In the tournament, they defeated six seed San Diego State in the First Round and three seed West Virginia in the Second Round, before losing to two seed Houston in the Sweet Sixteen.