The 2021–22 TCU Horned Frogs men's basketball team represented Texas Christian University during the 2021–22 NCAA Division I men's basketball season.

The team was led by sixth-year head coach Jamie Dixon, and played their home games at Schollmaier Arena in Fort Worth, Texas as a member of the Big 12 Conference.

5 seed in the Big 12 tournament, they defeated Texas in the quarterfinals, before losing to Kansas in the semifinals.

With their win over Seton Hall in the first round, the Horned Frogs won their first NCAA tournament game since 1987.

In a season limited due to the ongoing COVID-19 pandemic, the Horned Frogs finished the 2020–21 season 12–14, 5–11 in Big 12 play to finish in a tie for eighth place.