In addition to the domestic league, Hoffenheim participated in this season's edition of the DFB-Pokal.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Source: Soccerway Source: DFB The league fixtures were announced on 25 June 2021.