The four group winners qualify for the knockout phase, which features single-legged ties, again with no extra-time being played.
Thirty-four teams competing in the two professional tiers of Portuguese football for the 2021–22 season are eligible to participate in this competition.
For teams that were either promoted or related, the final position in the previous league season determines in which round they enter the competition.
Notes: In the second round, the fourteen first-round winners joined the two teams ranked 5th and 6th in the 2021–22 Primeira Liga.
In the third round, the eight second-round winners joined the four top-ranked teams from the 2020–21 Primeira Liga: Sporting CP (1st), Porto (2nd), Benfica (3rd) and Braga (4th).
[2] The knockout phase was contested as a final-four tournament by the four third-round group winners in one-legged semi-finals and final.