The 2021–22 Thai FA Cup is the 28th season of a Thailand's knockout football competition.

The tournament is organized by the Football Association of Thailand.

94 clubs were accepted into the tournament, and it began with the qualification round on 29 September 2021 and concluded with the final on 22 May 2022.

There were 13 clubs from 2021–22 Thai League 2, 28 clubs from 2021–22 Thai League 3, and 19 clubs from Thailand Amateur League have signed to qualifying in 2021–22 Thai FA cup.

Notes: 5 = Player scored 5 goals; 4 = Player scored 4 goals; (H) = Home team; (A) = Away team