[2] On April 9, 2022, the Maple Leafs clinched a playoff spot with a 3–2 win against the Montreal Canadiens.
The Maple Leafs qualified for the playoffs for the sixth consecutive season, but they were upset in the first round by the two-time defending Stanley Cup champion Tampa Bay Lightning, losing in seven games, despite leading the series 3–2 with a 3–2 lead after the 2nd period of Game 6.
(M) Player was playing for the minor league affiliate Toronto Marlies of the AHL at end of regular season (X) Player is no longer with the Maple Leafs organization (p) Player previously played with another team before being acquired by Toronto Bold/italics denotes franchise record.
Below are the Toronto Maple Leafs' selections at the 2021 NHL Entry Draft, which were held on July 23 to 24, 2021.
It was held virtually via video conference call from the NHL Network studio in Secaucus, New Jersey.