The 2021–22 Toto Cup Al is the 37th season of the third-important football tournament in Israel since its introduction and the 16th tournament involving Israeli Premier League clubs only.
[1] Maccabi Tel Aviv are the defending champions.
Maccabi Haifa and Maccabi Tel Aviv will play in the 2021 Israel Super Cup match for a place in one of the semi-finals (meeting the group winner with the least points accumulated), while F.C.
Ashdod and Hapoel Be'er Sheva will play for a place in the other semi-final (meeting the group winner with the most points accumulated) .
All clubs will participate in classification play-offs to determine their final positions.