The 2021–22 Telenet UCI Cyclo-cross World Cup was a season-long cyclo-cross competition, organized by the Union Cycliste Internationale (UCI).

The UCI Cyclo-cross World Cup took place between 10 October 2021 and 23 January 2022.

The top ten finishers received points according to the following table: Fourteen races were supposed to be held last season, but eventually, only five were held.

These five are also included this season but the calendar is expanded further to sixteen races, with last season's cancelled races in Antwerp, Besançon, Hoogerheide, Koksijde, Waterloo and Zonhoven returning to the calendar, as well as the race in Iowa which last featured in the 2019–20 season.

Entirely new will be the races in Fayetteville (United States), Flamanville (France), Rucphen (Netherlands) and Val di Sole (Italy).