This page summarises the Main Path matches of the 2021–22 UEFA Europa Conference League qualifying phase and play-off round.
FCI Levadia won 4–2 on aggregate.
Puskás Akadémia won 3–1 on aggregate.
FC Santa Coloma won 5–1 on aggregate.
Milsami Orhei won 1–0 on aggregate.
Śląsk Wrocław won 4–1 on aggregate.
Petrocub Hîncești won 2–1 on aggregate.
1–1 on aggregate; Gżira United won 5–3 on penalties.
Kauno Žalgiris won 2–0 on aggregate.
2–2 on aggregate; Shakhter Karagandy won 5–3 on penalties.
Hapoel Be'er Sheva won 6–0 on aggregate.
Maccabi Tel Aviv won 3–1 on aggregate.
0–0 on aggregate; CSKA Sofia won 3–1 on penalties.
2–2 on aggregate; Velež Mostar won 3–2 on penalties.
1–1 on aggregate; Lokomotiv Plovdiv won 3–2 on penalties.
1–1 on aggregate; Olimpija Ljubljana won 5–4 on penalties.
0–0 on aggregate; Raków Częstochowa won 4–3 on penalties.
1–1 on aggregate; Spartak Trnava won 4–3 on penalties.
Hapoel Be'er Sheva won 5–2 on aggregate.
0–0 on aggregate; Shakhter Karagandy won 3–1 on penalties.
Paços de Ferreira won 4–1 on aggregate.
5–5 on aggregate; Viktoria Plzeň won 4–1 on penalties.
Maccabi Tel Aviv won 1–0 on aggregate.
Maccabi Tel Aviv won 4–1 on aggregate.