Eintracht Frankfurt defeated Rangers 5–4 on penalties following a 1–1 draw after extra time in the final played at the Ramón Sánchez Pizjuán Stadium in Seville, Spain, winning the competition for the second time in club history, and the first since 1980.

Therefore, if in a two-legged tie, two teams scored the same number of aggregate goals, the winner of tie was not decided by the number of away goals scored by each team, but always by 30 minutes of extra time, and if the two teams scored the same number of goals in extra time, the winner was decided by a penalty shoot-out.

[9] Apart from the allocation based on the country coefficients, associations could have additional teams participating in the Europa League, as noted below: The following is the access list for this season.

[10] In the default access list, the title holders of the Europa Conference League qualified for the group stage.

However, since this berth was not used for this season, the following changes to the access list were made: The labels in the parentheses show how each team qualified for the place of its starting round: The third qualifying round was divided into Champions Path (CH) and Main Path (MP).

Scheduled kick-off times starting from the group stage were 18:45 (instead of 18:55 previously) and 21:00 CEST/CET, though exceptionally could take place at 16:30 due to geographical reasons.

On 16 July 2021, UEFA announced that the group stage draw would be held in Istanbul, Turkey.

The losers were transferred to the Europa Conference League play-off round of their respective path.

The draw for the group stage was held on 27 August 2021, 12:00 CEST (13:00 TRT), in Istanbul, Turkey.

In the knockout phase, teams played against each other over two legs on a home-and-away basis, except for the one-match final.