It was the first edition to feature a double-round-robin group stage, in the same manner as the men's UEFA Champions League.

The video assistant referee (VAR), previously only deployed for the final, was used for all matches in the knockout stage.

Therefore, if in a two-legged tie, two teams scored the same number of aggregate goals, the winner of tie was not decided by the number of away goals scored by each team, but always by 30 minutes of extra time, and if the two teams scored the same number of goals in extra time, the winner was decided by a penalty shoot-out.

[5] Barcelona were the defending champions, but lost the final to Lyon, who won a record eighth title.

With all participating countries now allowing full crowds for outdoor sporting events, attendance (from Group Stage onward) zoomed up to 552k, more than doubling the competition's previous record of 228k from the 2016-17 edition, helped by record crowds for women's club football (over 90,000) at both knockout matches held at Camp Nou.

As of 2019–20, 52 of the 55 UEFA member associations organize a women's domestic league, with the exceptions being Andorra, Liechtenstein and San Marino.

For example, if the title holders had not qualified for the group stage through league position and all 52 associations with a women's domestic league entered, the champions from associations 49–52 would enter the preliminary round.

[7] A preliminary round consisting of two-legged home-and-away matches would have been played by the champions from the lowest-ranked associations if more than 50 associations had entered the tournament and the title holders had not qualified through league position.

The third place play-off between Peamount United and Tbilisi Nike was cancelled following a decision taken by the Dutch health authorities to put the whole team of Tbilisi Nike into quarantine after a player had tested positive for COVID-19.

Clubs from countries with severe winter conditions (Sweden, Iceland) were assigned a position in their group which allowed them to play away on matchday 6.

Køge, 1899 Hoffenheim and Real Madrid played in a European competition for the first time this season.

In the knockout phase, teams played against each other over two legs on a home-and-away basis, except for the one-match final.

The UEFA technical study group selected the following players as the team of the tournament.