Portuguese side Benfica won their first title, beating Red Bull Salzburg 6–0 in the final.

Akademia e Futbollit, Angers, Deportivo La Coruña, Daugavpils, Empoli, Hajduk Split, 1.

FC Köln, Csíkszereda, Pogoń Szczecin, St Patrick's Athletic, Trabzonspor, Žalgiris and Zvijezda 09 will make their tournament debuts.

[2] The schedule of the competition is as follows (all draws were held at the UEFA headquarters in Nyon, Switzerland, unless stated otherwise).

There was no separate draw held, with the group compositions identical to the draw for the 2021–22 UEFA Champions League group stage, which was held on 26 August 2021, 18:00 CEST (19:00 TRT), in Istanbul, Turkey.

For the Domestic Champions Path, the 32 teams were drawn into two rounds of two-legged home-and-away ties.