The 2021–22 UEFA Youth League knockout phase began on 8 February 2022 with the play-off round and ended with the final on 25 April 2022 at Colovray Stadium in Nyon, Switzerland, to decide the champions of the 2021–22 UEFA Youth League.
The draw was conducted on 14 February 2022 12:00 CET at the UEFA headquarters in Nyon.
[10] The draw was conducted on 14 February 2022 12:00 CET at the UEFA headquarters in Nyon.
The semi-finals were played over one leg on 22 April 2022 at Colovray Stadium, Nyon.
[10] This was a replay of the 2017 UEFA Youth League Final, which Salzburg won 2–1.