The 2021–22 UNLV Runnin' Rebels basketball team represented the University of Nevada, Las Vegas during the 2021–22 NCAA Division I men's basketball season.

The Runnin' Rebels were led by first-year head coach Kevin Kruger and played their home games at the Thomas & Mack Center in Paradise, Nevada as members of the Mountain West Conference.

[1] In a season limited due to the ongoing COVID-19 pandemic, the Runnin' Rebels finished the 2020–21 season 12–15, 12–6 in Mountain West play to finish in seventh place.

They defeated Air Force in the first round of the Mountain West tournament before losing in the quarterfinals to Utah State.

On March 18, 2021, head coach T. J. Otzelberger left UNLV after two seasons for the Iowa State head coaching job.