The 2021–22 USC Trojans men's basketball team represented the University of Southern California during the 2021–22 NCAA Division I men's basketball season.

The Trojans are led by 9th-year head coach Andy Enfield and played their home games at the Galen Center for the 16th season in Los Angeles as members of the Pac-12 Conference.

3 seed in the Pac-12 tournament, they defeated Washington in the quarterfinals before losing in the semifinals to UCLA.

7 seed in the Midwest Region, where they lost in the First Round to Miami (FL).

They would then be invited to compete in the 2021 NCAA tournament and would get wins against Drake, Kansas, Oregon, but would then be eliminated by the Gonzaga Bulldogs in the Elite Eight.