Vipers SC won the championship with four games to go, finishing 18 points above second-placed KCCA.
[2] Onduparaka FC were docked two points and two goals and were made to replay their December match against KCCA after violence broke out when a penalty was awarded in the 5th minute of extra time.
[3] Three teams were promoted from the 2020–21 FUFA Big League, which ended early due to a 42-day lockdown as a result of the COVID-19 pandemic.
[4] Gaddafi FC were the third team promoted after defeating Proline 2–0 in the final of a four-team playoff held in August 2021.
[5] They replaced Kyetume FC, MYDA, and Kitara, who were relegated from the 2020–21 season.