The 2021–22 Ukrainian Amateur Cup season started on August 18, 2021.
[1] The competition was abandoned at semifinals stage due to the Russian aggression.
In bold are clubs that are active at the same season AAFU championship (parallel round-robin competition).
First leg games were scheduled to be played on 18 August and second leg on 25 August.
[1] Notes: Six other clubs Mayak Sarny, ODEK Orzhiv, Nyva Buzova, Olimpiya Savyntsi, Metalurh-2 Zaporizhia and Motor Zaporizhia received a bye to the round.