The competition was terminated at the PFL Council meeting on 6 May 2022 due to the 2022 Russian invasion of Ukraine.

[1] On June 1, 2021, the PFL Central Council adopted decision that new season competitions in the PFL Second League would start on July 25, 2021, just as competitions in all professional leagues in Ukraine.

[2] The competition format and league composition corresponds to the PFL program "Strategy of Development" that was adopted back in 2016.

[3] As the previous season the top 2 teams from each group get promoted to the First League.

In addition, the third placed teams in each group expected to contest a single berth for promotion play-off with the 12th place team of the 2021–22 First League.