The 2021–22 Vanderbilt Commodores women's basketball team represented Vanderbilt University during the 2021–22 NCAA Division I women's basketball season.

The Commodores, led by first-year head coach Shea Ralph, played their home games at Memorial Gymnasium and competed as members of the Southeastern Conference (SEC).

The Commodores finished the season 4–4 (0–3 SEC) after cutting their season short due to COVID-19.

Head coach Stephanie White was fired after five seasons.

UConn assistant Shea Ralph was hired to replace her.