In addition to the domestic league, VfL Wolfsburg participated in this season's editions of the DFB-Pokal and the UEFA Champions League, after finishing fourth in the previous Bundesliga season.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Source: Soccerway Source: DFB The league fixtures were announced on 25 June 2021.

[31] The draw for the group stage was held on 26 August 2021.