Led by head coach Jay Wright in his 21st and final year of coaching, the Wildcats played their home games at the Finneran Pavilion on the school's campus in the Philadelphia suburb of Villanova, Pennsylvania and Wells Fargo Center as members of the Big East Conference.

They defeated St. John's, UConn, and Creighton to win the Big East tournament championship.

On April 20, 2022, head coach Jay Wright announced he was retiring effective immediately.

They defeated Winthrop and North Texas to reach the Sweet 16, where they fell to eventual tournament champions Baylor 62–51.

[9] Roster Last update: July 8, 2021 Source[10] *Coaches did not release a week 1 poll.