[1] The Southside Flyers were the defending champions, however they failed to qualify for finals.
[2] The Melbourne Boomers won their second championship, defeating Perth in the Grand Final series, 2–1.
[3] After the 2020 season was condensed due to the COVID-19 pandemic, it was confirmed in July 2021 that the upcoming season is set to be closer to the traditional season fixture played over several months across the summer.
[4] In October 2021, a new broadcast deal was signed with the ABC, Fox Sports and Kayo,[5] with an 84-game season fixture announced shortly after.
[6] Spalding will again provide equipment including the official game ball, alongside iAthletic supplying team apparel for the fifth consecutive season.